Basal cell carcinoma - epidemiology, pathogenesis, pathology, and association with inflammation biomarkers. A review

• Rondon Ramalho

  Federal University of Mato Grosso do Sul

  https://orcid.org/0000-0002-6193-7521 (unauthenticated)

  Author

• Luiz Carlos Takita

  UFMS

  https://orcid.org/0000-0002-3047-4587 (unauthenticated)

  Author

• Cesar Augusto Sobrinho

  UFMS

  https://orcid.org/0000-0001-5115-4411 (unauthenticated)

  Author

• Marcel Arakaki Asato

  UFMS

  Author

• Gabriely Lessa Sacht

  UFMS

  Author

• Gunter Hans Filho

  UFMS

  https://orcid.org/0000-0001-9324-3703 (unauthenticated)

  Author

• Rondon Tosta Ramalho

  UFMS

  https://orcid.org/0000-0002-6193-7521 (unauthenticated)

  Author

• Ricardo Dutrra Aydos

  UFMS

  Author

Basal cell carcinoma is the most common malignant neoplasm in humans, with low mortality, high morbidity, and exposure to solar radiation (UVB and UVA) is the most critical risk factor. Ultraviolet B rays generate mutagenic photoproducts in DNA and mutations in important genes regulating cellular functions, such as the tumor suppressor gene TP53. Ultraviolet A rays generate cytotoxic and mutagenic free radicals, potentiating the effects of UVB rays.. There is current evidence to support the role of inflammatory biomarkers related to tumorigenesis of basal cell carcinoma.

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