In Vitro Antioxidant Potential of Baccharis trimera and Baccharis articulata Infusions in Postmenopausal Women

• Gabriela Tassotti Gelatti

  Unicruz

  Author

• Ana Caroline Tissiani

  Unicruz

  Author

• Mariana Spanamberg Mayer

  Unicruz

  Author

• Tamiris Felippin

  Unicruz

  Author

• Daiana Meggiolaro Gewehr

  Unicruz

  Author

• Jana Koefender

  Unicruz

  Author

• Evelise Moraes Berlezi

  unijui

  Author

• Diego Pascoal Golle

  unicruz

  Author

• Roberta Cattaneo Horn

  Unicruz

  Author

Considering that postmenopausal women generally have high levels of oxidative markers and low levels of antioxidant defense markers due to the reduction of estrogen levels, and because of the vast popular use of several species of carja in the form of infusion, this study aimed to evaluate in vitro if infusions of B. trimera and B. articulata have antioxidant potential in erythrocytes of postmenopausal women and which are the most effective. The erythrocytes from 40 postmenopausal women were treated in vitro for 1 hour with infusions of B. trimera and B. articulata at the following concentrations: 4, 8, 16, 33, 66 g/L. The negative control consisted of erythrocytes from postmenopausal women without treatment with the plants. After treatment, the levels of thiobarbituric acid reactive substances (TBARS), carbonylated proteins (CP), and reduced glutathione (GSH) were measured. The infusions of B. trimera and B. articulata at concentrations of 33 (p<0.001) and 66 g/L (p<0.001) reduced the level of TBARS in comparison to the negative control, and the effect size (ES) for this reduction was small. The levels of GSH increased after treating with B. trimera infusion at a concentration of 66 (p<0.001) and with B. articulata at concentrations of 33 (p<0.001) and 66 g/L (p<0.001), when compared with the negative control, and the ES for this increase was average. The infusions of B. trimera and B. articulata show antioxidant potential in vitro, thus showing a similar effect with regards to the reduction of oxidative damage to lipids and increased endogenous antioxidant protection.

1. Gabriela Tassotti Gelatti, Unicruz

    Laboratory of  Oxidative Stress and Medicinal Plants, Postgraduate Program in Integral Health Care, University of Cruz Alta (UNICRUZ), Rio Grande do Sul, Brazil in association with the Regional University of Northwestern Rio Grande do Sul State (UNIJUI), Rio Grande do Sul, Brazil.

2. Ana Caroline Tissiani, Unicruz

   Laboratory of  Oxidative Stress and Medicinal Plants, Postgraduate Program in Integral Health Care, University of Cruz Alta (UNICRUZ), Rio Grande do Sul, Brazil in association with the Regional University of Northwestern Rio Grande do Sul State (UNIJUI), Rio Grande do Sul, Brazil.

3. Mariana Spanamberg Mayer, Unicruz

   Laboratory of  Oxidative Stress and Medicinal Plants, Postgraduate Program in Integral Health Care, University of Cruz Alta (UNICRUZ), Rio Grande do Sul, Brazil in association with the Regional University of Northwestern Rio Grande do Sul State (UNIJUI), Rio Grande do Sul, Brazil.

4. Tamiris Felippin, Unicruz

   Laboratory of  Oxidative Stress and Medicinal Plants, Postgraduate Program in Integral Health Care, University of Cruz Alta (UNICRUZ), Rio Grande do Sul, Brazil in association with the Regional University of Northwestern Rio Grande do Sul State (UNIJUI), Rio Grande do Sul, Brazil.

5. Daiana Meggiolaro Gewehr, Unicruz

   Laboratory of  Oxidative Stress and Medicinal Plants, Postgraduate Program in Integral Health Care, University of Cruz Alta (UNICRUZ), Rio Grande do Sul, Brazil in association with the Regional University of Northwestern Rio Grande do Sul State (UNIJUI), Rio Grande do Sul, Brazil.

6. Jana Koefender, Unicruz

   Laboratory of  Culture in vitro, Professional Master in Rural Development, University of Cruz Alta (UNICRUZ), Rio Grande do Sul, Brazil.

7. Evelise Moraes Berlezi, unijui

   Laboratory of  Oxidative Stress and Medicinal Plants, Postgraduate Program in Integral Health Care, University of Cruz Alta (UNICRUZ), Rio Grande do Sul, Brazil in association with the Regional University of Northwestern Rio Grande do Sul State (UNIJUI), Rio Grande do Sul, Brazil.

8. Diego Pascoal Golle, unicruz

   Laboratory of  Culture in vitro, Professional Master in Rural Development, University of Cruz Alta (UNICRUZ), Rio Grande do Sul, Brazil.

9. Roberta Cattaneo Horn, Unicruz

   Laboratory of  Oxidative Stress and Medicinal Plants, Postgraduate Program in Integral Health Care, University of Cruz Alta (UNICRUZ), Rio Grande do Sul, Brazil in association with the Regional University of Northwestern Rio Grande do Sul State (UNIJUI), Rio Grande do Sul, Brazil.

    Laboratory of  Culture in vitro, Professional Master in Rural Development, University of Cruz Alta (UNICRUZ), Rio Grande do Sul, Brazil.

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Copyright (c) 2018 Gabriela Tassotti Gelatti, Ana Caroline Tissiani, Mariana Spanamberg Mayer, Tamiris Felippin, Daiana Meggiolaro Gewehr, Jana Koefender, Evelise Moraes Berlezi, Diego Pascoal Golle, Roberta Cattaneo Horn

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