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Etiological Factors of Autism Spectrum Disorder

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DOI:
https://doi.org/10.31686/ijier.vol8.iss8.2548
Keywords:
Array, Array, Array
Abstract

People with autism spectrum disorder (ASD) have multifactorial etiology, combined by different factors, both genetic, psychological and environmental; however, it´s necessary sharply discriminate those significant factors or components, regarding elaborate an early action protocol for diagnostic processes and subsequent intervention guidelines, which co A total of 192 participants with ASD of three intensity levels (American Psychiatric Association -APA-, 2013) have collaborated in this study. ASD diagnostic shape the discrimination´ aim to 18 independent variables, considered, a priori, potentially influential over diagnostic intrinsic process.

Results of discriminant analysis include two axes it delimits the two main functions, represented by two variables: "karyotype" (Wilks´ Lambda statistic= .88) and "diagnosis" (Wilks´ Lambda statistic= .83). Both variables are complemented along structure matrix of discriminant analysis with variable "gene" for first function ("karyotype") and variable "age" to second function ("diagnosis" + "karyotype").

These allow defining the general characteristics to establish an effective action protocol for the specific diagnosis, which constitutes the general aim of this empirical research.

 

References

American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders (DSM- 5) ®. Arlington: American Psychiatric Association. https://www.psychiatry.org/psychiatrists/practice/dsm DOI: https://doi.org/10.1176/appi.books.9780890425596

Andres, C. (2002). Molecular genetics and animal models in autistic disorder. Brain Res Bull, 57, 109-19. 10.1016/s0361-9230(01)00642-6. https://www.sciencedirect.com/science/article/abs/pii/S0361923001006426?via%3Dihub DOI: https://doi.org/10.1016/S0361-9230(01)00642-6

Artemios, P., Areti, S., Katerina, P., Helen, F., Eirini, T. & Charalambos, P. (2019). Autism Spectrum Disorder and psychiatric comorbidity in a patient with Myhre Syndrome. Journal of Autism and Developmental Disorders, 49(7), 3031-3035. http://dx.doi.org/10.1007/s10803-019-04015-y DOI: https://doi.org/10.1007/s10803-019-04015-y

Bayés, M., Ramos, J. A., Cormand, B., Hervás- Zúñiga, A., Campo, M., E. del, Duran-Tauleria, E., … y Estivill, X. (2014). AUTISMO Genotipado a gran escala en la investigación del trastorno del espectro autista y el trastorno por déficit de atención con hiperactividad. SIMPOSIO SATÉLITE: AUTISMO. Recuperado de: file:///C:/Users/Manuel/Desktop/Genotipado_a_gran_escala_en_la_investigacion_del_t%20(1).pdf.

Calahorro, F. (2011). Genética del autismo caenorhabditis elegans como modelo experimental en el estudio de la función sináptica neuronal. Tesis Doctoral. Córdoba: Universidad de Córdoba. https://helvia.uco.es/xmlui/handle/10396/5533

Camacho, R. J. (2013). Estudio de las bases genéticas de enfermedades del neurodesarrollo: Epilepsia y Autismo. Tesis Doctoral. Sevilla: Universidad de Sevilla. http://hdl.handle.net/10261/143281

Deciphering Developmental Disorders Study (2015). Large-scale discovery of novel genetic causes of developmental disorders. Nature, 519(7542): 223-228. https://www.ncbi.nlm.nih.gov/pubmed/25533962 DOI: https://doi.org/10.1038/nature14135

Demily, C., Lesca, G., Poisson, A., Till, M., Barcia, G., Chatron, N. … & Munnich, A. (2018). Additive effect of variably penetrant 22Q11.2 duplication and pathogenic mutations in Autism Spectrum Disorder: To which extent does the tree hide the forest? Journal of Autism and Developmental Disorders, 48(8), 2886-2889. http://dx.doi.org/10.1007/s10803-018-3552-7 DOI: https://doi.org/10.1007/s10803-018-3552-7

Doshi-Velez, F., Ge, Y., & Kohane, I., (2013). Comorbidity clusters in autism spectrum disorders: an electronic health record time series analysis. Pediatrics, 133(1), 54-63. DOI: https://doi.org/10.1542/peds.2013-0819

Freitag, C. M., Konrad, C., Haberlen, M., Kleser, C., von Gonfard, A., Reith, W., Troje, N. F., y Krick, C. (2008). Perception of biological motion in autism spectrum disorders. Neuropsychologia, 46(5), 1494-1494. DOI: https://doi.org/10.1016/j.neuropsychologia.2007.12.025

Gilissen, C., Hehir-Kwa, J.Y., Thung, D.T., van de Vorst, M., van Bon, B.W., Willemsen, M.H… &. Veltman, J.A. (2014). Genome sequencing identifies major causes of severe intellectual disability. Nature, 511(7509): 344-347. https://www.ncbi.nlm.nih.gov/pubmed/24896178 DOI: https://doi.org/10.1038/nature13394

Helsmoortel, C., Vandeweyer, G., Ordoukhanian, P., Van- Nieuwerburgh, F., Van der Aa, N. & Kooy, R.F. (2014). Challenges and opportunities in the investigation of unexplained intellectual disability using family-based whole-exome sequencing. Clin Genet. https://www.ncbi.nlm.nih.gov/pubmed/25081361 DOI: https://doi.org/10.1111/cge.12470

James, S. J., Shpyleva, S., Melnyk, S., Pavliv, O., & Pogribny, I. P. (2013). Complex epigenetic regulation of Engrailed-2 (EN-2) homeobox gene in the autism cerebellum. Translational Psychiatry, 3(2), e232. DOI: https://doi.org/10.1038/tp.2013.8

Kohane, I. S., McMurry, A., Weber, G., MacFadden, D., Rappaport, L., Kunkel, L., Bickel, J., Wattanasin, N., Spence, C., Murphy, S., & Churchill, S. (2012). The comorbidity burden of children and young adults with autism spectrum disorders. PlOS ONE, 7(4), e33224. DOI: https://doi.org/10.1371/journal.pone.0033224

Levy, S. E., Giarelli, E., Lee, L. C., Schieve, L. A., Kirby, R. S., Cunniff, C., Nicholas, J., Reaven, J., & Rice, C. E. (2010). Autism spectrum disorder and cooccurring developmental, psychiatric, and medical conditions among children in multiple populations of the United States. Journal of Developmental & Behavioral Pediatrics, 31(4), 267- 275. DOI: https://doi.org/10.1097/DBP.0b013e3181d5d03b

Mulhe, R., Trentacoste, S., & Rapin, I. (2004). The genetics of autism. Pediatrics, 113, e472- e486. DOI: https://doi.org/10.1542/peds.113.5.e472

Napoli, E., Russo, S., Casula, L., Alesi, V., Amendola, F. A., Angioni, A. … & Vicari, S. (2018). Array-CGH Analysis in a cohort of phenotypically Wwll-characterized individuals with "Essential" Autism Spectrum Disorders. Journal of Autism and Developmental Disorders, 48(2), 442-449. http://dx.doi.org/10.1007/s10803-017-3329-4 DOI: https://doi.org/10.1007/s10803-017-3329-4

Ojea, M. (2018). Trastorno del espectro autista. Procesamiento de la información percpetivo- cognitivo mediante la creación de redes semánticas. Madrid: Pirámide. https://www.edicionespiramide.es/libro.php?id=5151386

Oviedo, N., Manuel- Apolinar, L., Chesnaye, E. de la, Guerra- Araiza, C. (2015). Aspectos genéticos y neuroendocrinos en el trastorno del espectro autista. Bol Med Hosp Infant Mex, 72, 5-14. DOI: https://doi.org/10.1016/j.bmhimx.2015.01.010

Rubenstein, E., Wiggins, L. D., Schieve, L. A., Bradley, C., DiGuiseppi, C., Moody, E. … & Daniels, J. (2019). Associations between parental broader autism phenotype and child Autism Spectrum Disorder fhenotype in the study to explore early development. Autism: The International Journal of Research and Practice, 23(2), 436-448. http://dx.doi.org/10.1177/1362361317753563 DOI: https://doi.org/10.1177/1362361317753563

Ruherford, M. D., y Troje, N. F. (2012). IQ predicts biological motion perception in autism spectrum disorders. Journal of Autism and Developmental Disorders, 42(4), 557-565. DOI: https://doi.org/10.1007/s10803-011-1267-0

Tuchman, R., Hirtz, D, & Mamounas, L. A. (2013). NINDS epilepsy and autism spectrum disorders workshop report. Neurology, 81(18):1630- 1636. DOI: https://doi.org/10.1212/WNL.0b013e3182a9f482

US Department of Health and Human Services, Interagency Autism Coordinating Committee; National Institute of Mental Health (NIMH) (DHHS/NIH), Office of Autism Research Coordination (OARC) (2017). 2017 Summary of Advances in Autism Spectrum Disorder Research. Washington: Interagency Autism Coordinating Committee. https://eric.ed.gov/contentdelivery/servlet/ERICServlet?accno=ED589774

Veenstra-Van der Weele, J., y Cook E. H. (2004). Molecular genetics of autism spectrum disorder. Mol Psychiatry, 6, 1- 4.

Wright, C.F., Fitzgerald, T.W., Jones, W.D., Clayton, S., McRae, J.F., van Kogelenberg, M. … & Firth, H.V. (2015). Genetic diagnosis of developmental disorders in the DDD study: a scalable analysis of genome-wide research data. Lancet, 385(9975): 1305-1314. https://www.ncbi.nlm.nih.gov/pubmed/25529582 DOI: https://doi.org/10.1016/S0140-6736(14)61705-0

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Published
2020-08-01
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Vol. 8 No. 8 (2020): International Journal for Innovation Education and Research
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Journal Articles
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How to Cite

Manuel, O., Nuria, D., & María D., D. (2020). Etiological Factors of Autism Spectrum Disorder. International Journal for Innovation Education and Research, 8(8), 472-486. https://doi.org/10.31686/ijier.vol8.iss8.2548