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Meta-analysis: hydroxychloroquine therapy approach with or without azithromycin against covid-19

Authors

  • Josilene Nascimento do Lago

    University of Amazon (UNAMA)

    Author

  • Cosmo de Sousa Costa

    Federal University of Pará (UFPA)

    Author

  • Larissa Emily de Carvalho Moraes

    University of Amazon (UNAMA)

    Author

  • Raissa Ribeiro da Silva

    University of Amazon (UNAMA)

    Author

  • Gleiciane Moraes Gonçalves

    University of Amazon (UNAMA)

    Author

  • Thainar Stefanie Barbosa de Oliveira

    University of Amazon (UNAMA)

    Author

  • Tatiane Roseli Alves Castro

    Federal University of Viçosa (UFV)

    Author

  • Thalles Ricardo Melo de Souza

    State University of Pará (UEPA)

    Author

  • Christian Pacheco de Almeida

    State University of Pará (UEPA)

    Author

  • Lorena Victória de Souza Ferreira

    Paulista University (UNIP)

    Author

  • Alex Jean Ferreira da Silva

    University of Amazon (UNAMA)

    Author

  • Widson Davi Vaz de Matos

    Federal University of Pará (UFPA)

    Author

  • Renan Rocha Granato

    Federal University of Pará (UFPA)

    Author

  • Ademir Ferreira da Silva Júnior

    Federal University of Pará (UFPA)

    Author

DOI:
https://doi.org/10.31686/ijier.vol8.iss8.2493
Keywords:
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Abstract

Objective: identify and analyse the evidences about the use of hydroxychloroquine with or without azithromycin in covid-19. Methods: This is a systematic review with meta-analysis using posted articles in December 2019 until May 2020. The research was formulated by a question structured using PICO strategy, in these data bases: BVS, PUBMED, MEDLINE, LILACS, BDENF e SCIELO. Results and discussion: Resulted in 9 articles founded by the PRISMA, approaching 4182 patients. PICO strategy selected and analysed 5 articles projected in Forest plots. Resulting in tree clinical trials (RR: 1.15; IC95%, 0.76 a 1.73), which did not found big differences in the outcome in the groups of patients who used HCQ with or without AZT, comparing with the control group. Two studies analysed the number of deaths/intubations in comparative group, experimental group and control (RR:1.86; IC: 95%, 1.54 a 2.26) resulting in more chance of death /intubation in patients who used HCQ. Conclusion: It was found that is not possible to prove the efficacy of these drugs, due to the limited number of randomized and controlled clinical trials. Therefore, the encourage of scientific production about the HCQ and AZT against Covid-19 is more than necessary.

Author Biographies
  1. Josilene Nascimento do Lago, University of Amazon (UNAMA)

    Nursing Academic

  2. Cosmo de Sousa Costa, Federal University of Pará (UFPA)

    Medical Academic

  3. Larissa Emily de Carvalho Moraes, University of Amazon (UNAMA)

    Nursing Academic

  4. Raissa Ribeiro da Silva, University of Amazon (UNAMA)

    Nursing Academic

  5. Gleiciane Moraes Gonçalves, University of Amazon (UNAMA)

    Nursing Academic

  6. Thainar Stefanie Barbosa de Oliveira, University of Amazon (UNAMA)

    Nursing Academic

  7. Tatiane Roseli Alves Castro, Federal University of Viçosa (UFV)

    Nursing Academic

  8. Thalles Ricardo Melo de Souza, State University of Pará (UEPA)

    Medical Academic

  9. Christian Pacheco de Almeida, State University of Pará (UEPA)

    Physiotherapy Academic

  10. Lorena Victória de Souza Ferreira, Paulista University (UNIP)

    Nursing Academic

  11. Alex Jean Ferreira da Silva, University of Amazon (UNAMA)

    Nursing Academic

  12. Widson Davi Vaz de Matos, Federal University of Pará (UFPA)

    Resident Nurse, Oncology Nursing Residency Program

  13. Renan Rocha Granato, Federal University of Pará (UFPA)

    Physician in vascular surgery and adjunct professor of Medical Academy

  14. Ademir Ferreira da Silva Júnior, Federal University of Pará (UFPA)

    Post doctor in Safety of patient and associated Professor in Academy of Medicine 

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Published
2020-08-01
Issue
Vol. 8 No. 8 (2020): International Journal for Innovation Education and Research
Section
Journal Articles
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Copyright (c) 2020 Josilene Nascimento do Lago, Cosmo de Sousa Costa, Larissa Emily de Carvalho Moraes, Raissa Ribeiro da Silva, Gleiciane Moraes Gonçalves, Thainar Stefanie Barbosa de Oliveira, Tatiane Roseli Alves Castro, Thalles Ricardo Melo de Souza, Christian Pacheco de Almeida, Lorena Victória de Souza Ferreira, Alex Jean Ferreira da Silva, Widson Davi Vaz de Matos, Renan Rocha Granato, Ademir Ferreira da Silva Júnior

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How to Cite

Lago, J. N. do ., Costa, C. de S. ., Moraes, L. E. de C. ., Silva, R. R. da ., Gonçalves, G. M. ., Oliveira, T. S. B. de ., Castro, T. R. A. ., Souza, T. R. M. de ., Almeida, C. P. de ., Ferreira, L. V. de S. ., Silva, A. J. F. da ., Matos, W. D. V. de ., Granato, R. R. ., & Júnior, A. F. da S. . (2020). Meta-analysis: hydroxychloroquine therapy approach with or without azithromycin against covid-19. International Journal for Innovation Education and Research, 8(8), 73-87. https://doi.org/10.31686/ijier.vol8.iss8.2493